BIOMAT Database Logo BIOMAT Database Logo

Involvement of GABAergic mechanisms in the optokinetic nystagmus of the frog. 1983

N Bonaventure, and N Wioland, and J Bigenwald

Frog optokinetic nystagmus (OKN) was studied before and after an intravitreal injection of picrotoxin, a specific non-competitive GABA antagonist. In monocular vision, the OKN displayed a directional asymmetry favouring the Temporal-Nasal (T-N) stimulation. In that case, the nystagmus extinction frequency (NEF) is low, about 2 frames/s. In binocular vision, the OKN is symmetrical with a facilitation of performances compared to monocular vision (NEF = 3 frames/s). In monocular as in binocular vision, an intravitreal injection of picrotoxin (between 1 X 10(-4) and 5 X 10(-3) M) provoked the disappearance of the injected eye OKN and a spectacular facilitation in the performances of the intact eye, with the appearance of a N-T component and the increase of the NEF value reaching 7 or 11.5 frames/s according to the experimental conditions. This contralateral facilitation was no longer observed after the optic nerve of the injected eye had been cut, indicating that such a facilitation can only be explained by alterations of a central process triggered by the visual input. It is concluded that GABAergic mechanisms might be responsible for the inhibition of the N-T component in the frog OKN and might be involved in the control of the power of temporal resolution in this animal.

UI MeSH Term Description Entries
D009433 Neural Inhibition The function of opposing or restraining the excitation of neurons or their target excitable cells. Inhibition, Neural
D009760 Nystagmus, Physiologic Involuntary rhythmical movements of the eyes in the normal person. These can be naturally occurring as in end-position (end-point, end-stage, or deviational) nystagmus or induced by the optokinetic drum (NYSTAGMUS, OPTOKINETIC), caloric test, or a rotating chair. Nystagmus, Barany,Nystagmus, Caloric,Nystagmus, End-Position,Nystagmus, Positional,Nystagmus, Post-Rotatory,Nystagmus, Thermal,Nystagmus, Barany's,Nystagmus, Physiological,Physiologic Nystagmus,Barany Nystagmus,Barany's Nystagmus,Caloric Nystagmus,End-Position Nystagmus,Nystagmus, Baranys,Nystagmus, End Position,Nystagmus, Post Rotatory,Physiological Nystagmus,Positional Nystagmus,Post-Rotatory Nystagmus,Thermal Nystagmus
D010852 Picrotoxin A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8,Cocculin
D011896 Rana temporaria A species of the family Ranidae occurring in a wide variety of habitats from within the Arctic Circle to South Africa, Australia, etc. European Common Frog,Frog, Common European,Common European Frog,Common Frog, European,European Frog, Common,Frog, European Common
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005680 gamma-Aminobutyric Acid The most common inhibitory neurotransmitter in the central nervous system. 4-Aminobutyric Acid,GABA,4-Aminobutanoic Acid,Aminalon,Aminalone,Gammalon,Lithium GABA,gamma-Aminobutyric Acid, Calcium Salt (2:1),gamma-Aminobutyric Acid, Hydrochloride,gamma-Aminobutyric Acid, Monolithium Salt,gamma-Aminobutyric Acid, Monosodium Salt,gamma-Aminobutyric Acid, Zinc Salt (2:1),4 Aminobutanoic Acid,4 Aminobutyric Acid,Acid, Hydrochloride gamma-Aminobutyric,GABA, Lithium,Hydrochloride gamma-Aminobutyric Acid,gamma Aminobutyric Acid,gamma Aminobutyric Acid, Hydrochloride,gamma Aminobutyric Acid, Monolithium Salt,gamma Aminobutyric Acid, Monosodium Salt
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

N Bonaventure, and N Wioland, and J Bigenwald
[Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs].
January 1992, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
N Bonaventure, and N Wioland, and J Bigenwald
Involvement of NMDA in a plasticity phenomenon observed in the adult frog monocular optokinetic nystagmus.
June 1997, Vision research,
N Bonaventure, and N Wioland, and J Bigenwald
Neuronal pathways involved in the optokinetic head nystagmus of the frog.
January 1989, Acta biologica Hungarica,
N Bonaventure, and N Wioland, and J Bigenwald
Directional asymmetry of the frog monocular optokinetic nystagmus: cholinergic modulation.
March 1992, Vision research,
N Bonaventure, and N Wioland, and J Bigenwald
Involvement of ON and OFF retinal channels in the eye and head horizontal optokinetic nystagmus of the frog.
January 1989, Visual neuroscience,
N Bonaventure, and N Wioland, and J Bigenwald
Abolition of monocular optokinetic nystagmus directional asymmetry after unilateral visual deprivation in adult vertebrates: involvement of the GABAergic mechanism.
May 1990, Brain research. Developmental brain research,
N Bonaventure, and N Wioland, and J Bigenwald
Role of the accessory optic system in the optokinetic nystagmus of the frog.
January 1972, Brain, behavior and evolution,
N Bonaventure, and N Wioland, and J Bigenwald
Optokinetic nystagmus.
January 1954, Documenta ophthalmologica. Advances in ophthalmology,
N Bonaventure, and N Wioland, and J Bigenwald
Optokinetic nystagmus.
January 1974, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
N Bonaventure, and N Wioland, and J Bigenwald
[Optokinetic nystagmus].
August 1956, Ceskoslovenska neurologie,
Copied contents to your clipboard!