-transparent.png){kind=logo}
Twelve patients with refractory rheumatoid arthritis were treated with total lymphoid irradiation (TLI) to a total cumulative dose of 3,000 rads. Post-TLI morbidity/mortality included 8 patients with xerostomia, 4 with weight loss of greater than 10 kg, 3 with loss of 4 or more teeth, 3 with herpes zoster, 4 with bacterial infection that was fatal in 2, 3 with hypothyroidism, 1 with cutaneous vasculitis, and death from myocardial infarction in 1 patient and cardiorespiratory arrest in another. Ten of the patients were reevaluated 15-40 months (mean +/- SE, 30 +/- 2) after completion of TLI, and significant improvement was noted in several disease parameters including number of swollen joints, duration of morning stiffness, and 50-foot walking time. Blood lymphopenia and a decrease in helper T cells (T4) were also noted. These data suggest that changes in immunoregulation induced by TLI can produce longlasting alterations in rheumatoid arthritis, although adverse effects may limit its efficacy.
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
March 1997,
Arthritis and rheumatism,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
November 1985,
Arthritis and rheumatism,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
September 1987,
Arthritis and rheumatism,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
January 1987,
Arthritis and rheumatism,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
February 1986,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
January 1982,
Lancet (London, England),
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
January 1981,
Transactions of the Association of American Physicians,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
October 1981,
The New England journal of medicine,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
December 1986,
The British journal of radiology,
E Brahn, and
S M Helfgott, and
J A Belli, and
R J Anderson, and
E L Reinherz, and
S F Schlossman, and
K F Austen, and
D E Trentham
September 1997,
Lancet (London, England),
