Biomaterial Database

Facilitatory effects of electrical stimulation of the hippocampus on a one way active avoidance response in cats. 1983

K Gralewicz, and S Gralewicz

Effects of a low intensity electrical stimulation of the hippocampus (HiSt) on acquisition, performance and retention of a one-way active avoidance response (AAR) were studied in four groups of cats. The animals were first trained in avoiding an electric foot-shock signalled by a CS (500 Hz tone) presentation and then they were tested or retention until the response extinguished. The HiSt was applied simultaneously with the CS presentation and terminated immediately after the performance of the AAR. One group of cats was stimulated during training, one during the retention test, one during training and during the retention test and one served as unstimulated control group. It was found that application of the HiSt during training did not influence the acquisition rate, but the stimulation became indispensable for a normal performance and for retention of the response. Application of the HiSt after training facilitated performance and improved retention, but only in cats unstimulated during training. Additional tests revealed that the facilitatory effects of the HiSt could not be attributed to disinhibitory or cue properties of the HiSt.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D012153	Retention, Psychology	The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.	Psychological Retention,Retention (Psychology),Psychology Retention,Retention, Psychological
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001362	Avoidance Learning	A response to a cue that is instrumental in avoiding a noxious experience.	Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance