-transparent.png){kind=logo}
The effect of vitamin A deficiency on the drug-metabolizing enzyme system of the lung and liver was analyzed in rats fed diets with or without vitamin A for 5-6 weeks. The hepatic level of vitamin A was significantly reduced in vitamin A deficient animals. The hepatic cytochrome P-450 and b5 contents and activity of benzo(a)pyrene hydroxylase was significantly reduced in deficient animals. Contrary to this, pulmonary cytochrome P-450 and b5 contents were above the control values. No alteration in pulmonary benzo(a)pyrene hydroxylase was noted. The uridine diphosphate-glucuronosyltransferase activity of digitonin-treated microsomal membranes was below the control values both in lung and liver. However, the native uridine diphosphate-glucuronosyltransferase activity remained unchanged in the liver and was below control values in the lung.
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
July 1989,
Biochemistry international,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
January 1990,
Biochemistry international,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
June 1984,
The Indian journal of medical research,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
July 1974,
Biochemical pharmacology,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
September 1986,
The Indian journal of medical research,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
July 1977,
Toxicology and applied pharmacology,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
February 1980,
Japanese journal of pharmacology,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
January 1982,
Developmental pharmacology and therapeutics,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
January 1989,
Acta psychiatrica Scandinavica. Supplementum,
S C Dogra, and
K L Khanduja, and
M P Gupta, and
R R Sharma
January 1978,
General pharmacology,
