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This paper reviews the evidence for two different forms of carbohydrate-mediated recognition of lysosomal enzymes by cell surface receptors. The recognition marker on lysosomal enzymes which are rapidly pinocytosed by fibroblasts contains phosphate, probably linked to D-mannose as a phosphomannosyl moiety. The fraction of lysosomal hydrolases bearing this recognition marker for fibroblasts varies, depending on the tissue source. Another form of recognition accounts for rapid plasma clearance of infused lysosomal enzymes in the rat. This rapid clearance is mediated by receptors on Kupffer cells and other reticuloendothelial cells that recognize mannosyl residues on the glycoprotein hydrolases.
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
January 1988,
Indian journal of biochemistry & biophysics,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
February 1984,
The Biochemical journal,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
January 1983,
Methods in enzymology,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
January 1986,
Hepatology (Baltimore, Md.),
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
July 1988,
Pediatric research,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
November 1990,
The EMBO journal,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
March 1979,
Experimental cell research,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
September 2017,
The Journal of biological chemistry,
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
April 1983,
Ryumachi. [Rheumatism],
W S Sly, and
A Kaplan, and
D T Achord, and
F E Brot, and
C E Bell
April 1972,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
