Biomaterial Database

Detection of bone marrow invasion by neuroblastoma is improved by sampling at two sites with both aspirates and trephine biopsies. 1983

I M Franklin, and J Pritchard

Two hundred and eight serial bone marrow samples from 49 consecutively diagnosed children with neuroblastoma were studied retrospectively for evidence of tumour invasion. Bone marrow involvement was found in 24 patients at diagnosis and in four more at a later stage in their disease. Trephine biopsies were more effective than aspirates for tumour detection in 20% of the 154 paired aspirate/trephine procedures, whilst the reverse was the case in 7%. Imprints of trephines gave no additional information. Bilateral sampling (aspirates and trephines) improved the tumour detection rate by 10% over that attained by sampling a single site. There was some correlation between specific appearances in aspirate and in trephine samples, for example the hypocellular smear and the trephine biopsy showing much stromal reaction to tumour infiltration. Bilateral iliac crest bone marrow aspirates and trephine biopsies are indicated in children with neuroblastoma, both for initial staging and for monitoring of progress.

UI	MeSH Term	Description	Entries
D007085	Ilium	The largest of three bones that make up each half of the pelvic girdle.	Auricular Surface of Ilium,Iliac Crest,Iliac Crest Bone,Iliac Fossa,Bones, Iliac Crest,Crest Bone, Iliac,Crest Bones, Iliac,Crest, Iliac,Crests, Iliac,Fossa, Iliac,Iliac Crest Bones,Iliac Crests,Iliums
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D009361	Neoplasm Invasiveness	Ability of neoplasms to infiltrate and actively destroy surrounding tissue.	Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D009447	Neuroblastoma	A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	Neuroblastomas
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D001855	Bone Marrow Diseases	Diseases involving the BONE MARROW.	Bone Marrow Disease,Disease, Bone Marrow,Diseases, Bone Marrow,Marrow Disease, Bone,Marrow Diseases, Bone
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females