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In a crossover study of six healthy volunteers the pharmacokinetics and the bioavailability of vincamine were studied after administration of two oral forms. All subjects received an oral dose of 60 mg vincamine. The plasma concentrations of the drug were determined by a specific and sensitive gas chromatographic method. In this kind of subject the drug generally follows a one-compartment kinetic model. The average value of Tmax is 1.4 +/- 0.5 h-1 with the tablets and 1 +/- 0.6 h-1 with the solution; the Cmax are, respectively, 155 +/- 82 micrograms . 1(-1) and 133 +/- 104 micrograms . 1(-1). The AUC are 443 +/- 156 micrograms . 1(-1) h with the tablets and 315 +/- 178 micrograms . 1(-1) h with the solution. The short elimination phases, 1.43 +/- 0.80 h with the tablets and 1.55 +/- 0.78 h with the solution should be taken into account during chronic administration.
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
October 1955,
Minerva farmaceutica,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
February 1988,
Journal of the American Academy of Dermatology,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
January 1976,
Pharmaceutica acta Helvetiae,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
January 1984,
International journal of clinical pharmacology research,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
December 1981,
The American journal of clinical nutrition,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
January 2014,
Drug design, development and therapy,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
December 1992,
American journal of veterinary research,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
January 2017,
Antimicrobial agents and chemotherapy,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
June 2010,
Investigational new drugs,
H Millart, and
D Lamiable, and
G Houin, and
M Plat, and
H Choisy, and
J P Tillement
October 1989,
Contraception,
