Biomaterial Database

[Study of autonomy of action of white gene in allophenic mice]. 1978

V V Osipov, and M P Vakhrusheva

An allophenic mouse and three allophenic embryos were obtained by aggregating 8-cell-embryos of Miwh/Miwh and +/+ genotypes. The coat colour and pigment epithelium of the eyes indicated chimerism. Melanoblasts of genotype Miwh/Miwh were lost during the embryonic development. Variations of coat colour in a chimeric mouse were due to the interaction of normal melanocytes with the surrounding dermal cells which consisted of clones of Miwh/Miwh or +/+ genotypes and a mixture of both. Certain differences between the right (chimeric) and left (normal) eye development and a greater rate of normal clones growth were observed in the allophenic mouse. Pigmentation of the eyes of two allophenic embryos was less than normal. This indicated the autonomy of gene white action in mice.

UI	MeSH Term	Description	Entries
D008544	Melanocytes	Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.	Melanocyte
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002678	Chimera	An individual that contains cell populations derived from different zygotes.	Hybrids,Chimeras,Hybrid
D005127	Eye Color	Color of the iris.	Color, Eye,Colors, Eye,Eye Colors
D005260	Female		Females
D005796	Genes	A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.	Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes
D006200	Hair Color	Color of hair or fur.	Color, Hair,Colors, Hair,Hair Colors