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Effects of danazol plus testosterone enanthate on rabbit vas deferens are investigated. Seminal, biochemical tissue and histological studies were performed. Sperm motility was markedly impaired with the advancement of treatment. At the end of treatment 75 per cent of the animals became azoospermic. Seminal fructose did not change, whereas citric acid showed a progressive non-significant increase. Phosholipid and protein contents of vas deferens decreased during drug exposure. No appreciable changes were observed in sialic acid concentration. Citric acid and fructose in ampullae reduced following 60 days of treatment. Vas deferens lumen was devoid of spermatozoa. The combination therapy impaired the secretory activity of vas deferens reversibly.
N K Lohiya, and
R C Sharma
February 1998,
Indian journal of experimental biology,
N K Lohiya, and
R C Sharma
May 1951,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
N K Lohiya, and
R C Sharma
January 1984,
General pharmacology,
N K Lohiya, and
R C Sharma
December 1982,
Fukushima journal of medical science,
N K Lohiya, and
R C Sharma
September 2005,
Clinical and experimental pharmacology & physiology,
N K Lohiya, and
R C Sharma
April 2005,
The Journal of clinical endocrinology and metabolism,
N K Lohiya, and
R C Sharma
July 1976,
European journal of pharmacology,
N K Lohiya, and
R C Sharma
September 1970,
Investigative urology,
N K Lohiya, and
R C Sharma
October 1961,
Bollettino della Societa italiana di biologia sperimentale,
N K Lohiya, and
R C Sharma
March 2001,
Fertility and sterility,
