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Effects of medroxy progesterone acetate (MPA; 5 mg/kg) and MPA + testosterone enanthate (TE) (3 mg + 2 mg/kg) were investigated in vas deferens and on fertility (along with reversibility study) for 60 days through histopathology, morphometric and certain biochemical parameters such as total proteins, sialic acid, ATPase, SDH and testosterone. The study revealed for altered histopathology and contratile pattern of vas deferens resulting in reduced fertility. The study also indicated androgen antagonistic effect. These effects were found to be reversible 4 and 3 months after withdrawal of MPA and MPA + TE injections respectively. Thus, both types generated functional sterility in the rat, but MPA affected histophysiology of vasal tissue.
M V Rao, and
G K Roy, and
S N Prasannalata
January 1983,
Acta Europaea fertilitatis,
M V Rao, and
G K Roy, and
S N Prasannalata
January 1974,
Minerva urologica,
M V Rao, and
G K Roy, and
S N Prasannalata
January 1972,
Acta obstetricia et gynecologica Scandinavica. Supplement,
M V Rao, and
G K Roy, and
S N Prasannalata
April 1976,
The Indian journal of medical research,
M V Rao, and
G K Roy, and
S N Prasannalata
January 1976,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M V Rao, and
G K Roy, and
S N Prasannalata
November 2003,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M V Rao, and
G K Roy, and
S N Prasannalata
January 1984,
General pharmacology,
M V Rao, and
G K Roy, and
S N Prasannalata
December 1977,
Horumon to rinsho. Clinical endocrinology,
M V Rao, and
G K Roy, and
S N Prasannalata
January 2003,
Fertility and sterility,
M V Rao, and
G K Roy, and
S N Prasannalata
February 1970,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
