Biomaterial Database

The carcinogenic effect of nitrosopiperidine administered in the drinking water of Syrian golden hamsters. 1983

M B Ketkar, and R Fuhst, and R Preussmann, and U Mohr

Syrian golden hamsters (Mesocricetus auratus W.) were used to test the long-term carcinogenic effect of nitrosopiperidine (NP). Groups of 30 females and 30 males were given 0.05%, 0.025% and 0.006% NP in their drinking water for life. The animals developed neoplasms in the larynx, pharynx, trachea and forestomach (papillary polyps, papillomas and epidermoid carcinomas) and in the liver (hepatocellular adenomas, carcinomas). In addition, cholangiocellular and endothelial liver tumours and colon adenocarcinomas were observed. The overall tumour frequency was dose-dependent and higher in males than in females.

UI	MeSH Term	Description	Entries
D008113	Liver Neoplasms	Tumors or cancer of the LIVER.	Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008297	Male		Males
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009602	Nitrosamines	A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.	Nitrosamine
D011336	Probability	The study of chance processes or the relative frequency characterizing a chance process.	Probabilities
D012142	Respiratory Tract Neoplasms	Tumors or cancer of the RESPIRATORY SYSTEM.	Respiratory Neoplasms,Respiratory System Neoplasms,Neoplasm, Respiratory,Neoplasm, Respiratory System,Neoplasm, Respiratory Tract,Respiratory Neoplasm,Respiratory System Neoplasm,Respiratory Tract Neoplasm
D002273	Carcinogens	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.	Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004067	Digestive System Neoplasms	Tumors or cancer of the DIGESTIVE SYSTEM.	Cancer of Digestive System,Digestive System Cancer,Cancer of the Digestive System,Neoplasms, Digestive System,Cancer, Digestive System,Cancers, Digestive System,Digestive System Cancers,Digestive System Neoplasm,Neoplasm, Digestive System
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response