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The effects of aging on cytosolic glutathione S-transferase activities were evaluated with liver and lung cytosol from male and female Fischer 344 rats 3, 12, and 24 months of age. Age-related changes were tissue-, sex-, and substrate-specific. With liver and lung cytosol from both males and females, rates of metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane and p-nitrobenzyl chloride were lower in the old group than in the young group; however, patterns of decrease differed with tissue and sex. With 1,2-dichloro-4-nitrobenzene, metabolism was affected by aging only in liver and lung cytosol from males. Finally, with 1-chloro-2,4-dinitrobenzene, metabolic rates were altered during aging only with liver cytosol from females. However, the apparent Km was higher with liver cytosol from old males; those values from lung cytosol of males and liver or lung cytosol from females were unchanged. These data indicate that changes in the cytosolic glutathione S-transferase isozymes occurred during aging.
M E Spearman, and
K C Leibman
April 1991,
Biochimica et biophysica acta,
M E Spearman, and
K C Leibman
September 2002,
Toxicological sciences : an official journal of the Society of Toxicology,
M E Spearman, and
K C Leibman
January 1980,
European journal of drug metabolism and pharmacokinetics,
M E Spearman, and
K C Leibman
July 2018,
Physiological reports,
M E Spearman, and
K C Leibman
January 1986,
Toxicology,
M E Spearman, and
K C Leibman
June 2004,
The Journal of pharmacy and pharmacology,
M E Spearman, and
K C Leibman
May 1989,
Mechanisms of ageing and development,
M E Spearman, and
K C Leibman
January 1988,
Gerontology,
M E Spearman, and
K C Leibman
January 1994,
Experimental gerontology,
M E Spearman, and
K C Leibman
December 1987,
Alcoholism, clinical and experimental research,
