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The effect of intravenous injection of nonachlazine on the infarction size in rabbits was studied planimetrically 7 days after coronary artery occlusion. The first group rabbits received the drug 5 times every 30 minutes, beginning from the 30th minute after occlusion (the total dose 15 mg/kg). The second group rabbits were given nonachlazine 3 times a day (the total dose 12 mg/kg) during 6 days, beginning from the 2nd day after coronary artery occlusion. In both the animal groups, the drug induced respectively a 22.8 and 39.4% decrease in the necrosis size as compared to control. The effect of nonachlazine is presumably linked with stimulation of the collateral coronary circulation in the occluded zone and with the drug direct action on myocardial metabolism.
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1982,
Farmakologiia i toksikologiia,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1980,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
February 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1978,
Kardiologia polska,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1990,
The American journal of cardiovascular pathology,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
June 1987,
American heart journal,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
November 1981,
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S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1982,
Advances in shock research,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
January 1982,
Basic research in cardiology,
S V Gatsura, and
N M Cherpachenko, and
A I Turilova, and
N I Afonskaia, and
Iu B Pozonov
March 1984,
The Indian journal of medical research,
