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Leiomyoblastoma of the stomach is exceedingly rare. The authors report the case of a 69-year-old woman who presented with acute epigastric pain, anemia and weight loss. She was found to have a malignant leiomyoblastoma (epithelioid leiomyosarcoma) of the duodenum with lymph-node involvement. The clinical and pathological aspects of leiomyoblastoma of the gastrointestinal tract are reviewed, with emphasis on the distinctive, diagnostic histologic features. To the authors' knowledge, this is only the fourth reported case of leiomyoblastoma of the duodenum and the only case in which the tumour was malignant.
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