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Fourteen cases of adenocarcinoma with pleuritis carcinomatosa (lung cancer 10 cases, ovarian cancer 2 cases, colon cancer 2 cases) were treated with intra-pleural instillation of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083), a derivative of mitomycin C. KW-2083 was administered at a dose of 40 mg once or twice weekly. In 14 evaluable patients, the rate of decrease of pleural fluid was 79%, and that of disappearance of tumor cells in pleural fluid was 64%. Median survival time (MST) from the beginning of treatment in all cases was 163 days. The toxicities of intrapleural instillation of KW-2083 were chest pain (86%), transient fever (64%), anorexia (64%), fatigability (29%), nausea (21%), vomiting (21%) and thrombocytopenia (nadir: 3.5 X 10(4)/mm3; 7%). Serum and pleural fluid KW-2083 concentrations have been measured in 3 patients after intrapleural administration of KW-2083. The mean half life of KW-2083 in serum and pleural fluid was 74 min (69-78 min) and 56 min (33-70 min), respectively. The peak serum KW-2083 concentration was 0.18 microgram/ml (0.06-0.24 microgram/ml).
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
September 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
January 1982,
Gan no rinsho. Japan journal of cancer clinics,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
December 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
January 1984,
Investigational new drugs,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
August 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
December 1981,
Gan,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
October 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
May 1983,
The Journal of antibiotics,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
September 1984,
Nucleic acids research,
E Shimizu, and
N Saijo, and
T Shinkai, and
K Eguchi, and
K Tominaga, and
H Nomori, and
Y Sasaki, and
P Garcia-Herreros, and
A Hoshi
December 1981,
Gan,
