Biomaterial Database

Renal handling and lymph concentration of tetroxoprim and metioprim: an experimental study in dogs. 1984

P Iversen, and H Vergin, and P O Madsen

The renal handling and renal lymph concentrations of tetroxoprim and metioprim, 2 trimethoprim analogs, were investigated during constant intravenous infusion in 8 dogs. The mean ratios of tetroxoprim and metioprim clearance to creatinine clearance were 0.40 and 0.16 respectively. After compensation for protein binding, both antimicrobials were found to undergo a renal tubular net reabsorption of 55 to 60 per cent of the filtered amount. Renal lymph was obtained by direct cannulation of capsular lymphatics, and the mean lymph-to-arterial plasma concentration ratios were 0.93 and 0.74 for tetroxoprim and metioprim, respectively. Renal tissue concentrations of the 2 microbials were many times higher than the simultaneous concentrations in plasma, suggesting that lymph concentrations do not represent the entire interstitial compartment or that significant amounts of antimicrobial are located intracellularly. Tetroxoprim and metioprim concentrated well in the kidney, but their potential use in the treatment of pyelonephritis awaits verification in clinical trials.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D008297	Male		Males
D011743	Pyrimidines	A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000890	Anti-Infective Agents	Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.	Anti-Infective Agent,Anti-Microbial Agent,Antimicrobial Agent,Microbicide,Microbicides,Anti-Microbial Agents,Antiinfective Agents,Antimicrobial Agents,Agent, Anti-Infective,Agent, Anti-Microbial,Agent, Antimicrobial,Agents, Anti-Infective,Agents, Anti-Microbial,Agents, Antiinfective,Agents, Antimicrobial,Anti Infective Agent,Anti Infective Agents,Anti Microbial Agent,Anti Microbial Agents
D014295	Trimethoprim	A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.	Proloprim,Trimpex