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The role of both intracellular and extracellular Ca2+ pools in the expression of alpha-adrenergic-agonist-mediated responses was examined in perfused rat liver. Responses studied included glycogenolysis, respiration, lactate and pyruvate formation, ketone-body production, changes in the cytoplasmic and mitochondrial redox ratio and cellular K+ fluxes. Each of these was shown to be dependent on the mobilization of intracellular Ca2+ and can be grouped into one of two response types. Transient responses (ion fluxes and the redox ratios) are obligatorily dependent on the mobilization of intracellular Ca2+ and occur irrespective of the extracellular Ca2+ concentration. Sustained responses, on the other hand, initially require intracellular Ca2+ and, subsequently, extracellular Ca2+. The data indicate that alpha-adrenergic agonists mobilize extracellular Ca2+ as well as intracellular Ca2+ and that both pools are required for the full expression of hormone-induced responses in rat liver.
P H Reinhart, and
W M Taylor, and
F L Bygrave
March 1986,
European journal of biochemistry,
P H Reinhart, and
W M Taylor, and
F L Bygrave
March 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
P H Reinhart, and
W M Taylor, and
F L Bygrave
January 1986,
The Biochemical journal,
P H Reinhart, and
W M Taylor, and
F L Bygrave
June 1985,
Journal of dental research,
P H Reinhart, and
W M Taylor, and
F L Bygrave
January 1994,
Archives internationales de pharmacodynamie et de therapie,
P H Reinhart, and
W M Taylor, and
F L Bygrave
May 1980,
The Biochemical journal,
P H Reinhart, and
W M Taylor, and
F L Bygrave
June 1993,
Cell calcium,
P H Reinhart, and
W M Taylor, and
F L Bygrave
May 1983,
The Biochemical journal,
P H Reinhart, and
W M Taylor, and
F L Bygrave
December 1982,
The Journal of biological chemistry,
P H Reinhart, and
W M Taylor, and
F L Bygrave
January 1982,
The Journal of biological chemistry,
