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The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary bladder found in weeks 12 and 24 in rats treated with BBN and EHBN were preneoplastic papillary or nodular hyperplasia (PN hyperplasia), papilloma and cancer. The incidences and numbers of these lesions per 10 cm of basement membrane of urinary bladder were increased significantly by ureteric ligation. Treatment with BBN or EHBN only induced no remarkable change and thus the doses used were subcarcinogenic in the conditions used. The results show that unilateral ureteric ligation enhanced two-stage bladder carcinogenesis.
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
September 1983,
Cancer research,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
November 1996,
Japanese journal of cancer research : Gann,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
October 1983,
Gan,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
July 1987,
Cancer research,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
July 1997,
Japanese journal of cancer research : Gann,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
January 1982,
Carcinogenesis; a comprehensive survey,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
September 1985,
Japanese journal of cancer research : Gann,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
June 1995,
Japanese journal of cancer research : Gann,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
November 1983,
Cancer letters,
Y Miyata, and
S Fukushima, and
K Imaida, and
N Ito
November 1999,
Cancer letters,
