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Estimation of GFR using radioisotope techniques has been successfully accomplished with I-125 iothalamate, Cr-51 EDTA, and Tc-99m DTPA. However, the techniques have required up to several hours to complete with blood and/or urine sampling. A method introduced by Schlegel and modified by Gates provides a simple and rapid technique of GFR quantitation that obviates the need for blood and urine sampling. In the present study an evaluation of Tc-99m GHA was undertaken to assess its ability to reflect GRF using a modification of Gates' technique. When the GFR determinations were compared with a current 24-hour CrC1, a correlation coefficient of 0.91 was obtained. Tc-99m GHA-derived GFR appears to closely correlate with endogenous CrC1 over a wide range of renal function.
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