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The role of serotonin (5-HT) in the control of serum cortisol secretion was studied in 50 conscious beagle dogs. A significant rise in corticosteroids was observed after 1.5 and 3 mg/kg (P less than 0.01) iv fenfluramine, an indirect serotonergic agonist, as well as after 2 (P less than 0.05) and 3 mg/kg (P less than 0.01) iv quipazine, a direct agonist of 5-HT receptors. Both drugs exhibited a dose-related effect. A lower dose of fenfluramine, 0.5 mg/kg, was ineffective when administered iv, but raised serum cortisol (P less than 0.05) after direct injection into a lateral cerebral ventricle, through a chronically implanted brain cannula. The marked increases in corticosteroid concentration produced by the highest fenfluramine and quipazine doses were completely abolished by pretreatment with ketanserin, an antagonist of 5-HT2 receptors, which did not affect cortisol secretion when administered alone. These data suggest that brain serotonergic system plays a role in the control of cortisol secretion in conscious dogs.
C Barbieri, and
M Sala, and
G Bigatti, and
W G Rauhe, and
A Guffanti, and
A Diena, and
D Scorza, and
M Bevilacqua, and
G Norbiato
January 2019,
Acta physiologica (Oxford, England),
C Barbieri, and
M Sala, and
G Bigatti, and
W G Rauhe, and
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A Diena, and
D Scorza, and
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G Norbiato
January 1996,
Behavioural brain research,
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G Norbiato
October 1977,
Journal of neurochemistry,
C Barbieri, and
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October 1985,
Acta endocrinologica,
C Barbieri, and
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G Norbiato
January 1993,
Psychoneuroendocrinology,
C Barbieri, and
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W G Rauhe, and
A Guffanti, and
A Diena, and
D Scorza, and
M Bevilacqua, and
G Norbiato
February 1988,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C Barbieri, and
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G Norbiato
September 1980,
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G Norbiato
June 1971,
The Journal of clinical endocrinology and metabolism,
C Barbieri, and
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G Norbiato
August 1969,
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C Barbieri, and
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G Norbiato
October 1990,
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