A stochastic-mechanical model of longitudinal long bone growth. 1984

M Shinozuka, and A Tsurui, and T Naganuma, and M Moss, and L Moss-Salentijn

A typical mammalian long bone will increase in length during the growth phase of the individual. This increase in length does not occur uniformly throughout the bone, since bone tissue is incapable of internal expansion after formation. The growth occurs at two, disc-shaped, regions near either end of the long bone. These regions are called growth plates. These plates are located between the osseous shaft (diaphysis) and osseous tip (epiphysis) whose bone tissues are discontinuous. The present study develops a stochastic-mechanical model for such a bone growth and demonstrates the capability of the model to reproduce the observed overall behavior of longitudinal long bone growth based on realistic information of cellular mitosis, growth and ossification. A numerical analysis was performed on the model under the assumption that the number of cells in the proliferation zone remains constant throughout the growth period. The growth curves thus obtained compare favorably with those growth curves proposed elsewhere essentially on the basis of phenomenological observation. The present model can demonstrate the effects of such parameters as the proliferation rate, initial age distribution and compressive stress on the growth. More importantly, the stochastic-mechanical model so developed permits one to incorporate further experimental evidence and statistical observation at the cellular level into the analysis to improve the solutions.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011336 Probability The study of chance processes or the relative frequency characterizing a chance process. Probabilities
D001846 Bone Development The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS. Bone Growth
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D006132 Growth Plate The area between the EPIPHYSIS and the DIAPHYSIS within which bone growth occurs. Cartilage, Epiphyseal,Epiphyseal Cartilage,Epiphyseal Plate,Cartilages, Epiphyseal,Epiphyseal Cartilages,Epiphyseal Plates,Growth Plates,Plate, Epiphyseal,Plate, Growth,Plates, Epiphyseal,Plates, Growth
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001696 Biomechanical Phenomena The properties, processes, and behavior of biological systems under the action of mechanical forces. Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic

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