Biomaterial Database

[Immunization of calves with a rabies vaccine from suckling mouse brain]. 1981

A M Díaz, and R A Lombardo

Centro Panamericano de Zoonosis, OPS/OMS, Buenos Aires.

This paper summarizes the results obtained in a study on the duration of immunity in calves immunized with suckling mouse brain (SMB) rabies vaccine, supplemented with aluminum hydroxide. Rabies circulating antibodies were detected ten days after vaccination in 100% of the 31 vaccinated calves. They began to decrease 90 days after immunization. Of the 15 calves challenged one year postimmunization, 5 (33%) had no detectable antibodies at serum dilution 1:5, but all were protected against the challenge dose virus which killed 75% (3/4) of the non vaccinated controls. The results obtained suggest that SMB rabies vaccine can be used successfully to immunize calves aged from 7 days to 6 months. Since 15 to 20% of the cattle population of a country is less than one-year-old, the protection of this population against rabies with an inactivated vaccine would decrease the number of susceptible animals and facilitate both the vaccination procedures and the movement of animals from rabies-free areas to those where the disease is enzootic.

UI	MeSH Term	Description	Entries
D011819	Rabies Vaccines	Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.	Rabies Human Diploid Cell Vaccine,Rabies Vaccine,Vaccine, Rabies,Vaccines, Rabies
D011820	Rabies virus	The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.	Rabies viruses
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000914	Antibodies, Viral	Immunoglobulins produced in response to VIRAL ANTIGENS.	Viral Antibodies
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus