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In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory mestrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days on the average, by a preovulatory surge) is not directed by alterations in hypothalamic gonadotropin-releasing hormone secretion but by the ebb and flow of ovarian estrogens acting directly on the pituitary gland.
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
September 1991,
Endocrinology,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
April 1993,
Neuroendocrinology,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
March 1987,
The Journal of comparative neurology,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
June 1995,
Proceedings of the National Academy of Sciences of the United States of America,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
May 1981,
Endocrinology,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
January 1986,
Progress in clinical and biological research,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
August 1987,
The Journal of clinical endocrinology and metabolism,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
January 1988,
Human reproduction (Oxford, England),
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
June 1989,
Metabolism: clinical and experimental,
E Knobil, and
T M Plant, and
L Wildt, and
P E Belchetz, and
G Marshall
December 1995,
Endocrine journal,
