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In the glucocorticoid-sparing test, which shows certain advantages compared with other experimental procedures, the clinical efficacy of the new antirheumatic substance piroxicam (Feldene) was investigated. It was shown that a single daily dose of 20 mg piroxicam gave at least an equal, if not better, effect compared with other substances tested earlier, as far as comparison is permissible between two collectives treated with different substance. The mean saving of prednisone was 5.7 mg/day and according to another evaluation 64.7% of the previously required dose of prednisolone. It is worth noting that owing to the long half-life there is a remarkable clinical effect over at least 24 hours with a single daily dose. Tolerance was good. Pathological laboratory values which were definitely to be attributed to the preparation were not seen in a trial period of a maximum of four weeks.
H Mathies, and
E Wolff
January 1980,
Arzneimittel-Forschung,
H Mathies, and
E Wolff
May 1980,
Wiener medizinische Wochenschrift (1946),
H Mathies, and
E Wolff
September 1975,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
H Mathies, and
E Wolff
September 1979,
Klinika oczna,
H Mathies, and
E Wolff
March 1976,
Nihon Shishubyo Gakkai kaishi,
H Mathies, and
E Wolff
February 1978,
MMW, Munchener medizinische Wochenschrift,
H Mathies, and
E Wolff
June 1975,
Klinische Wochenschrift,
H Mathies, and
E Wolff
February 1975,
Wiener klinische Wochenschrift,
H Mathies, and
E Wolff
January 1980,
ZFA. Zeitschrift fur Allgemeinmedizin,
H Mathies, and
E Wolff
February 1976,
Immunitat und Infektion,
