Effect of intermittent-flow centrifugation leukapheresis on donor leukocyte counts. 1980

R G Strauss, and L C Maguire, and J A Koepke, and J S Thompson

Effects of intermittent-flow centrifugation leukapheresis (IFCL) on leukocyte counts in donor blood have not been reported. Accordingly, total and differential white blood cell counts were preformed serially during IFCL. A significant decrease (p less than 0.05) in all types of leukocytes occurred in donor blood early in pheresis and was probably the consequence of hemodilution. Concentrations of most leukocyte types remained decreased throughout the procedure, and a rebound leukocytosis was not detected. Thus, leukocyte kinetics in donor blood during IFCL differ from those reported for filtration leukapheresis in which the pattern of selective neutropenia followed by rebound neutrophilia has been ascribed to complement activation.

UI MeSH Term Description Entries
D007937 Leukapheresis The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor. Leukocytapheresis,Leukopheresis,Lymphapheresis,Lymphocytapheresis,Leukocytopheresis,Lymphocytopheresis,Lymphopheresis,Leukaphereses,Leukocytaphereses,Leukocytophereses,Leukophereses,Lymphaphereses,Lymphocytaphereses,Lymphocytophereses,Lymphophereses
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D002498 Centrifugation Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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