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The purpose of this work was to investigate the distribution in chromatin of deoxyribonucleic acid (DNA) adducts of aflatoxin B1, following exposure in vivo. Rainbow trout were injected intraperitoneally with radiolabeled aflatoxin B1, a potent procarcinogen known to readily induced hepatocellular carcinomas in these fish. After maximum incorporation, liver nuclei were prepared and digested with micrococcal nuclease. Mono-, di-, and trinucleosomal fractions were purified from several stages of nuclease digestion, and the lengths and specific activities of their DNA were determined. The results indicate that aflatoxin B1 is approximately 5 times as likely on a per nucleotide basis to localize on internucleosomal (linker) DNA as on nucleosomal core DNA in this system.
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
January 1995,
Cancer research,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
February 1982,
Gastroenterologie clinique et biologique,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
April 1995,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
October 1992,
Pharmacology & toxicology,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
April 1982,
Journal of the National Cancer Institute,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
September 1990,
Carcinogenesis,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
January 1980,
Carcinogenesis,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
January 1979,
Journal of environmental pathology and toxicology,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
January 1991,
Toxicologic pathology,
G S Bailey, and
J E Nixon, and
J D Hendricks, and
R O Sinnhuber, and
K E Van Holde
April 1980,
Biochemistry,
