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Ten patients presenting for carniotomy were studied. Each was anaesthetized with thiopentone or Althesin followed by tubocurarine and the lungs were hyperventilated with nitrous oxide in oxygen. Fentanyl 0.2 mg was administered i.v. and the intracranial pressure (i.c.p.) and mean arterial pressure were recorded continuously for 10 min. At the time of administration of fentanyl nine of the 10 patients were hypocapnic (PaCO2 less than 4 kPa). The changes in i.c.p. were small. Cerebral perfusion pressures less than 50 mm Hg were observed in two patients who had moderate hypotension before the drug was given. We conclude that fentanyl is a valuable agent in the hyperventilation technique in patients with intracranial space-occupying lesions, provided that hypotension is absent.
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
October 1976,
British journal of anaesthesia,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
November 1983,
British journal of anaesthesia,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
January 1988,
Revista espanola de anestesiologia y reanimacion,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
January 2002,
Acta neurochirurgica. Supplement,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
December 1991,
Journal of neurosurgical anesthesiology,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
July 2005,
Journal of neurosurgery,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
April 1986,
Anesthesia and analgesia,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
March 2004,
Neurosurgery,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
March 1972,
Masui. The Japanese journal of anesthesiology,
E Moss, and
D Powell, and
R M Gibson, and
D G McDowall
January 2000,
Journal of neurosurgery,
