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Although the relations between the metabolic state and the mechanical properties of human red blood cells (RBC) continue to be of current interest, literature reports in this area are not in agreement. The present investigation was designed to determine several intrinsic mechanical properties of human RBC membranes before and after metabolic depletion via incubation at 37 degrees C for 24 hr. Using micropipette and flow channel techniques, three properties were measured: (1) mu, surface shear modulus of elasticity; (2) K, elastic area compressibility modulus; (3) etap, shear viscosity in the plastic domain. Our results indicate no significant differences in these parameters between fresh and ATP-depleted human RBC membranes. These present data are thus in disagreement with other literature reports indicating large changes in membrane mechanical properties consequent to metabolic depletion. A brief discussion of the possible reasons for this disagreement is presented.
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1977,
Biorheology,
H J Meiselman, and
E A Evans, and
R M Hochmuth
October 1982,
Journal of general microbiology,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 2016,
Tsitologiia,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1992,
Advances in experimental medicine and biology,
H J Meiselman, and
E A Evans, and
R M Hochmuth
February 1996,
Mechanisms of ageing and development,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1991,
Ukrainskii biokhimicheskii zhurnal (1978),
H J Meiselman, and
E A Evans, and
R M Hochmuth
February 1981,
The Journal of clinical investigation,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1978,
Journal of supramolecular structure,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1972,
Nouvelle revue francaise d'hematologie,
H J Meiselman, and
E A Evans, and
R M Hochmuth
January 1986,
Biomedica biochimica acta,
