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Six mutagenic and/or carcinogenic agents were tested for their ability to cause somatic eye mutation (red sectors on a yellow eye) in Drosophila melanogaster. Results were analysed by the chi-squared method and by the Kolmogorov-Smirnov two-sample (non-parametric) test. Methyl methanesulphonate, cyclophosphamide, acriflavine and procarbazine were active, whereas acetamide and tetracycline failed to elicit a significant response. Thus, relative to other mutagenicity assays, this somatic system seemed to possess no special ability to correctly identify carcinogens because both acriflavine and acetamide were misidentified on a carcinogenicity basis. However, it could be a suitable alternative to the recessive lethal test for mutation, because of its technical simplicity and rapidity, subject to an increase in the size of the data base.
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
January 1984,
Environmental mutagenesis,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
September 1979,
Mutation research,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
January 1996,
Environmental and molecular mutagenesis,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
February 1992,
Mutation research,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
September 1986,
Proceedings of the National Academy of Sciences of the United States of America,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
June 1987,
Mutation research,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
April 1991,
Mutation research,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
January 1989,
Gigiena truda i professional'nye zabolevaniia,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
November 2009,
Mutation research,
I D Mitchell, and
P J Gilbert, and
A J Brice, and
D J White
May 2010,
PLoS genetics,
