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The effect on platelet function of a monoclonal platelet antibody to platelet membrane glycoprotein I was tested. This antibody, AN51, inhibited ristocetin or bovine factor VIII-induced aggregation but did not modify ADP, collagen type I or type III, thrombin or arachidonic acid induced aggregations. Furthermore, the adhesion-aggregation of platelets induced by microfibrils was also inhibited by the antibody. Platelet adhesion to rabbit aorta subendothelium was impaired by the antibody. The persistent adhesion of platelets to collagenase-treated subendothelium was also inhibited. These findings strongly suggested that platelet membrane glycoprotein I could interact with a non-collagenic microfibrillar component of subendothelium. The binding of factor VIII/von Willebrand factor to platelet membrane in the presence of ristocetin was decreased in the binding site for factor VIII/von Willebrand factor to allow platelet adhesion to subendothelium.
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
April 1987,
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
December 2003,
Journal of thrombosis and haemostasis : JTH,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
January 1991,
Platelets,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
August 1988,
Thrombosis and haemostasis,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
June 1985,
Thrombosis research,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
February 1987,
Zhonghua yi xue za zhi,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
December 1990,
Blood,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
January 1990,
Haematologica,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
June 2011,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
C Ruan, and
G Tobelem, and
A J McMichael, and
L Drouet, and
Y Legrand, and
L Degos, and
N Kieffer, and
H Lee, and
J P Caen
August 1984,
British journal of haematology,
