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N-Monoethyl derivatives of carminomycin, rubomycin, 13-dihydrocarminomycin and 13-dihydrorubomycin were synthesized by condensation of their amino groups with acetic aldehyde in the presence of sodium boron hydride. The respective N,N-diethyl derivatives of the antibiotics were formed as by-products of the reaction. New compounds such as N-ethylcarminomycin, N,N-diethylcarminomycin, N-ethyl-13-dihydrocarminomycin, N,N-diethyl-13-dihydrocarminomycin, N-ethylrubomycin and N-ethyl-13-dihydrorubomycin were synthesized. Antibacterial activity of N-ethyl- and N,N-diethyl derivatives of carminomycin and rubomycin determined with the use of Bac. mycoides as the test microbe was 40-50 per cent and that of N-ethyl- and N,N-diethyl-13-dihydro-derivatives was 15-30 per cent of the activity of the respective antibiotics, carminomycin and rubomycin.
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
October 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
July 1979,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
January 1983,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
January 1991,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
October 1990,
Bioorganicheskaia khimiia,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
February 1979,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
January 1977,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
November 1976,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
June 1984,
Antibiotiki,
E N Olsuf'eva, and
L S Povarov, and
N P Potapova
June 1978,
Antibiotiki,
