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Interaction of 14-bromine derivatives of daunorubicin and carminomycin, as well as their aglycones with secondary amines, such as piperidine, N-methylpiperazine and morpholine was studied with a purpose of preparing new potentially antitumor antibiotics. It was found that reaction in acetone or dioxan at a temperature of 50--60 degrees C resulted in formation of 14-amino derivatives of the respective bromides. 14-Piperidinyl- and 14-(N-methylpiperazinyl)-daunorubicin, 14-piperidinyl-daunorubicinon and 14-piperidinyl-carminomycinon were prepared. The structure of the new substances was confirmed by the IR, UV and NMR spectra. The antimicrobial activity of 14-amino derivatives amounted to 10--35 per cent of the activity of the initial antibiotics, i.e. daunorubicin and carminomycin.
L S Povarov, and
N N Isaeva
June 1990,
Bioorganicheskaia khimiia,
L S Povarov, and
N N Isaeva
September 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
L S Povarov, and
N N Isaeva
November 1980,
Journal of medicinal chemistry,
L S Povarov, and
N N Isaeva
January 1982,
Antibiotiki,
L S Povarov, and
N N Isaeva
May 1980,
Antibiotiki,
L S Povarov, and
N N Isaeva
October 1982,
Antibiotiki,
L S Povarov, and
N N Isaeva
June 1997,
Nucleic acids research,
L S Povarov, and
N N Isaeva
April 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
L S Povarov, and
N N Isaeva
September 1977,
The Journal of antibiotics,
L S Povarov, and
N N Isaeva
February 1983,
Antibiotiki,
