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In cerebrospinal fluid from controls ("non-diseased probands", n = 326) the following variables were determined: albumin and immunoglobulin G (by immunodiffusion) and total protein. Total protein rose parallel with the age of the subjects (r = 0.319); the albumin fractions (r = 0.126) and immunoglobulin G (r = 0.144) also correlated with age. The concentrations of albumin and immunoglobulin G were correlated even more closely (r = 0.589), leading to a particularly slender form of the elliptic bivariate normal range. The correlation of the variables albumin and immunoglobulin G with each other and with age was drawn upon as additional information, in order to discriminate between laboratory findings from diseased and from non-diseased subjects: a trivariate area of reference ("trivariate normal range") was calculated, which avoided errors of the second kind (diseased values not recognized) more powerfully than the usual one-dimensional ranges (x +/- 2s or percentile).
W Bernhardt, and
B Weisner, and
W Rehpenning
January 1992,
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui,
W Bernhardt, and
B Weisner, and
W Rehpenning
September 1979,
Journal of clinical microbiology,
W Bernhardt, and
B Weisner, and
W Rehpenning
December 1980,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
W Bernhardt, and
B Weisner, and
W Rehpenning
December 1977,
Der Nervenarzt,
W Bernhardt, and
B Weisner, and
W Rehpenning
May 1976,
Klinische Padiatrie,
W Bernhardt, and
B Weisner, and
W Rehpenning
October 1974,
Scandinavian journal of clinical and laboratory investigation,
W Bernhardt, and
B Weisner, and
W Rehpenning
August 1978,
Archiv fur Psychiatrie und Nervenkrankheiten,
W Bernhardt, and
B Weisner, and
W Rehpenning
June 1979,
Rinsho byori. The Japanese journal of clinical pathology,
W Bernhardt, and
B Weisner, and
W Rehpenning
October 1980,
Clinical chemistry,
W Bernhardt, and
B Weisner, and
W Rehpenning
January 1980,
No to shinkei = Brain and nerve,
