Biomaterial Database

Genetic effects of 1,2-dibromo-3-chloropropane (DBCP) in Drosophila. 1982

P G Kale, and J W Baum

Induction of sex-linked recessive lethal mutations, heritable translocations and genetic crossing-over were studied in Drosophila melanogaster males treated as adults and as embryos with different concentrations of gaseous DBCP. Adults exposed to 30 ppm/hr of the compound did not produce a significant number of sex-linked recessive lethal mutations in treated spermatozoa, spermatids, or spermatocytes. However, at an exposure of 17.7 ppm/hr, a weak mutagenic effect was observed in embryonic spermatogonia. No translocation was scored in 4032 tested chromosomes from adults treated with 150 ppm/hr. However, a significant number of spermatocytial crossovers were induced after an exposure of 120 ppm/hr.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009153	Mutagens	Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.	Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D011407	Propane	A three carbon alkane with the formula H3CCH2CH3.
D004331	Drosophila melanogaster	A species of fruit fly frequently used in genetics because of the large size of its chromosomes.	D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D005804	Genes, Lethal	Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.	Alleles, Lethal,Allele, Lethal,Gene, Lethal,Lethal Allele,Lethal Alleles,Lethal Gene,Lethal Genes
D005808	Genes, Recessive	Genes that influence the PHENOTYPE only in the homozygous state.	Conditions, Recessive Genetic,Genetic Conditions, Recessive,Recessive Genetic Conditions,Condition, Recessive Genetic,Gene, Recessive,Genetic Condition, Recessive,Recessive Gene,Recessive Genes,Recessive Genetic Condition
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor

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