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Twenty-two patients with chronic lymphocytic leukemia, score 2 according to Rai et al. (10), who received only a course of splenic irradiation are reviewed. Splenic doses ranged from 420 to 1080 rad. Response to splenic irradiation was rated by evaluating peripheral lymphocytosis, hepatosplenomegaly, adenomegaly and disease-related symptoms. Following splenic irradiation, 8 patients showed a significant reduction in splenomegaly; 7 patients showed a significant reduction in peripheral lymphocytosis (less than 10,000/mm3), which has lasted from 15-42 months without any other treatment. In 14 patients, response to splenic irradiation was partial, and it has successively been necessary to treat 12 patients with chemotherapy. Methods of splenic irradiation, survival, clinical and hematologic behavior are discussed in detail.
G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
April 1991,
European journal of haematology,
G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
January 1968,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
October 1969,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
June 1975,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
October 1987,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
January 1989,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
April 1968,
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G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
November 1988,
European journal of haematology,
G De Rossi, and
C Biagini, and
M Lopez, and
V Tombolini, and
F Mandelli
January 1983,
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