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The conformational change upon binding with phospholipid membrane has been studied of mastoparan from wasp venom, a tetradecapeptide causing the degranulation of mast cells. The 270-MHz 1H-NMR spectra and CD spectra indicate that the mastoparan molecule takes the alpha-helical conformation in methanol solution, but a much less ordered form in aqueous solution. On binding with phospholipid membrane, the alpha-helical conformation is formed even in aqueous medium. Such a conformational change is primarily due to the interaction between the aliphatic side chains of mastoparan and the hydrophobic interior of phospholipid membrane, in contrast to the case of melittin from bee venom.
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
August 1990,
Biochimica et biophysica acta,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
March 1993,
FEBS letters,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
October 2017,
Toxicon : official journal of the International Society on Toxinology,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
July 1990,
Biochemical and biophysical research communications,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
November 1980,
International journal of peptide and protein research,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
May 1988,
The Journal of biological chemistry,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
July 1992,
FEBS letters,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
September 2004,
The journal of peptide research : official journal of the American Peptide Society,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
July 1996,
Biochemistry,
T Higashijima, and
K Wakamatsu, and
M Takemitsu, and
M Fujino, and
T Nakajima, and
T Miyazawa
August 1997,
British journal of pharmacology,
