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The influence of ascorbic acid supplementation on the copper status of young adult men was investigated. Subjects consuming self-selected diets took 500 mg of ascorbic acid with each meal (1500 mg/day) for 64 days. Blood samples were obtained at 0, 28, 52, and 64 days in order to determine serum copper and serum ceruloplasmin. Each subject thus served as his own control. Analyses were repeated 20 days after the ascorbic acid supplement was terminated. Serum ceruloplasmin activity was significantly reduced (p less than 0.01) at every data point throughout the ascorbic acid supplementation period. A similar but nonsignificant trend was observed for serum copper. Furthermore there was a significant increase (p less than 0.01) in serum copper concentration 20 days after the supplementation period. Although observed effects occurred within physiological ranges of normal values, this study confirms that a high ascorbic acid intake is antagonistic to copper status of men as has been demonstrated in laboratory animals.
E B Finley, and
F L Cerklewski
November 1992,
The British journal of nutrition,
E B Finley, and
F L Cerklewski
January 1989,
Biological trace element research,
E B Finley, and
F L Cerklewski
April 1983,
The American journal of clinical nutrition,
E B Finley, and
F L Cerklewski
January 1990,
Annals of nutrition & metabolism,
E B Finley, and
F L Cerklewski
January 1989,
Advances in experimental medicine and biology,
E B Finley, and
F L Cerklewski
December 1987,
The Journal of nutrition,
E B Finley, and
F L Cerklewski
October 1984,
The American journal of clinical nutrition,
E B Finley, and
F L Cerklewski
November 1987,
Clinical science (London, England : 1979),
E B Finley, and
F L Cerklewski
January 1975,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
E B Finley, and
F L Cerklewski
May 1998,
Equine veterinary journal,
