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The effect of cinoxacin on p-aminohippurate (PAH) transport and the accumulation of cinoxacin were examined in renal cortical slices. Cinoxacin significantly inhibited the uptake of PAH by the slices from rats and rabbits. Cinoxacin increased the apparent Michaelis constant (Km) but did not affect Vmax for PAH uptake by rat kidney cortical slices, suggesting that cinoxacin inhibited PAH transport in a competitive manner. Cinoxacin was taken up but did not affect the cellular metabolism of Na+, K+ and ATP in the slices from rats and rabbits, except that 740 microM cinoxacin increased net Na+ efflux. These data indicate that cinoxacin is transported by the same process as that of PAH in renal cortical slices. Lastly, repeated administration of cinoxacin to rats did not affect the uptake of the drug by the slices.
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
March 1981,
Journal of pharmacobio-dynamics,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
July 1977,
The Journal of endocrinology,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
March 1979,
The Journal of physiology,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
December 1990,
The Journal of pharmacology and experimental therapeutics,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
June 1981,
Japanese journal of pharmacology,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
September 1973,
Archives internationales de physiologie et de biochimie,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
October 1983,
Journal of pharmacobio-dynamics,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
July 1982,
British journal of pharmacology,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
December 1982,
Biochimica et biophysica acta,
M Gemba, and
T Komamura, and
Y Matsushima, and
T Itoh, and
K Miyata, and
M Nakamura
October 1977,
Biochemical pharmacology,
