-transparent.png){kind=logo}
The genotoxicity of cimetidine was examined in the hepatocyte primary culture/DNA-repair test and by the DNA-damage/alkaline-elution assay. A dose-dependent amount of unscheduled DNA synthesis was elicited by cimetidine, whereas DNA fragmentation occurred only in hepatocytes exposed to the highest (3 mM) concentration of the drug. These findings are in contrast with the negative results previously obtained in long-term and short-term carcinogenesis assays.
Related Publications
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 1986,
Cancer letters,
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 1990,
Methods in molecular biology (Clifton, N.J.),
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
September 1981,
Toxicology and applied pharmacology,
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 1997,
In vivo (Athens, Greece),
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 2006,
Methods in molecular biology (Clifton, N.J.),
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 2006,
Methods in molecular biology (Clifton, N.J.),
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
October 1979,
Biochemical and biophysical research communications,
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
July 1982,
Journal of toxicology and environmental health,
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
December 1978,
Cancer research,
A Martelli, and
M Cavanna, and
V Gambino, and
L Robbiano, and
G Brambilla
January 1983,
Toxicology and applied pharmacology,
