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Specific receptors with high affinity for dexamethasone (Kass = 2.03 = 4.04 . 10(8) M-1) were found in liver cytosole of control rats as well as in animals with hepatocarcinogenesis caused by diethylnitrosamine and in cytosole of primary hepatomas. Amount of the binding sites for dexamethasone varied depending on severity of the blastomatous process (3.4 = 0.17 X X 10(-13) M/mg protein). The receptors from liver tissue of control rats, malignant liver and hepatomas were similar in their binding patterns and in chromatigraphic properties. Content of dexamethasone-receptor complexes accepted by chromatin was decreased by 50% in cytosole of malignant liver cells as compared with controls. The same alteration in binding of cytosole-receptor complexes of DNA from malignant liver tissue was found by means of affinity chromatography.
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A P Ulinskaĭte, and
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R Iu Iurkshaĭtite
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K I Krauialis, and
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August 1989,
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Endokrinologie,
K I Krauialis, and
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L A Kil'dema, and
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R Iu Iurkshaĭtite
September 1979,
The Journal of biological chemistry,
K I Krauialis, and
A P Ulinskaĭte, and
L A Kil'dema, and
A P Diashrius, and
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March 1982,
Journal of steroid biochemistry,
K I Krauialis, and
A P Ulinskaĭte, and
L A Kil'dema, and
A P Diashrius, and
R Iu Iurkshaĭtite
February 1982,
Endokrinologie,
K I Krauialis, and
A P Ulinskaĭte, and
L A Kil'dema, and
A P Diashrius, and
R Iu Iurkshaĭtite
December 1986,
Biochemical pharmacology,
K I Krauialis, and
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R Iu Iurkshaĭtite
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