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We have described a patient with basophilic leukemia secondary to chronic granulocytic leukemia. Symptoms of hyperhistaminemia were aggravated after chemotherapy with hydroxyurea. Antihistamines (H1 receptor antagonists) controlled many of the symptoms related to hyperhistaminemia. Peptic ulcer disease with hemorrhage, however, is not controlled by H1 receptor blockade and was one of the contributing causes of death. Attempts to purify the leukemic basophils for chemical analysis met with only partial success. In treating patients with basophilic leukemia, supportive therapy for peptic ulcer disease as well as the use of cimetidine for gastric hyper acidity should be used routinely to avoid this potential complication of cytotoxic chemotherapy.
C V Jennings, and
C L Dannaher, and
L T Yam
January 1987,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
C V Jennings, and
C L Dannaher, and
L T Yam
September 1966,
Archives of internal medicine,
C V Jennings, and
C L Dannaher, and
L T Yam
January 1998,
Ryoikibetsu shokogun shirizu,
C V Jennings, and
C L Dannaher, and
L T Yam
January 1985,
Terapevticheskii arkhiv,
C V Jennings, and
C L Dannaher, and
L T Yam
January 1985,
Terapevticheskii arkhiv,
C V Jennings, and
C L Dannaher, and
L T Yam
January 1985,
Polskie Archiwum Medycyny Wewnetrznej,
C V Jennings, and
C L Dannaher, and
L T Yam
February 1960,
Minerva medica,
C V Jennings, and
C L Dannaher, and
L T Yam
August 2001,
European journal of haematology,
C V Jennings, and
C L Dannaher, and
L T Yam
January 1994,
Acta haematologica Polonica,
C V Jennings, and
C L Dannaher, and
L T Yam
June 1992,
American journal of clinical pathology,
