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Two hundred healthy adults were immunized with 1 microgram of the bacterial antigen monomeric flagellin from Salmonella adelaide, and grouped as responders and non-responders on the basis of a rise in titre of antibody 2 weeks after immunization. Immunoglobulin allotypes G1m(a), G1m(z) and G3m(g) were more frequent among responders who made immunoglobulin (Ig)G antibody (P less than 0.02), and HLA-B12 was more frequent among responders who made IgM antibody (P less than 0.05). The mean log titre of IgG antibody was higher in females (P less than 0.001), in subjects with T1m(a), G1m(z) and G3m(g) allotypes (P less than 0.05), and in Gm heterozygotes (P less than 0.01). The mean log titre of the IgG antibody response in subjects with particular Gm phenotypes was also dependent on the HLA-B locus phenotypes HLA-B7, B8 and B12 (P less than 0.005); for example, among those with the phenotype Gm(a-x-b) subjects with HLA-B7 were low responders and those with HLA-B8 were high responders. These findings are consistent with the hypothesis that there are immune response genes within the major histocompatibility complex (MHC) which interact with Gm-linked genes in determining levels of serum antibodies of different isotypes and specificities.
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J V Matthews, and
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P J Morris, and
I R Mackay
January 1987,
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S Whittingham, and
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M S Schanfield, and
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P J Morris, and
I R Mackay
July 1982,
Human immunology,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
September 2009,
The Journal of infectious diseases,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
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B D Tait, and
P J Morris, and
I R Mackay
May 1986,
Tissue antigens,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
January 1988,
Archivum immunologiae et therapiae experimentalis,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
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April 1983,
Tissue antigens,
S Whittingham, and
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M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
January 1987,
Immunogenetics,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
November 1993,
The Journal of rheumatology,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
July 1983,
British journal of diseases of the chest,
S Whittingham, and
J D Mathews, and
M S Schanfield, and
J V Matthews, and
B D Tait, and
P J Morris, and
I R Mackay
January 1995,
Autoimmunity,
