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A Chinese hamster cell mutant has been described with little or no activity of succinate dehydrogenase (SODERBERG et al., 1977). We described here the selection and characterization of human-hamster hybrids obtained from the fusion of these mutant cells and human lymphoblasts or HT1080 fibrosarcoma cells. The presence of human chromosome 1, identified by cytogenetic techniques and isozyme analysis, is correlated with the restoration of succinate dehydrogenase activity in the hybrids, and segregants are described in which the loss of all or part of human chromosome 1 has also led to a loss of this activity. We present in one of the two structural genes for the 70,000 and 30,000 dalton peptides, respectively, which constitute succinate dehydrogenase. One of these two genes is therefore mapped on human chromosome 1.
J T Mascarello, and
K Soderberg, and
I E Scheffler
May 1984,
Proceedings of the National Academy of Sciences of the United States of America,
J T Mascarello, and
K Soderberg, and
I E Scheffler
January 1974,
Proceedings of the National Academy of Sciences of the United States of America,
J T Mascarello, and
K Soderberg, and
I E Scheffler
January 1984,
Human genetics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
January 1978,
Cytogenetics and cell genetics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
November 1993,
Genomics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
January 1979,
Cytogenetics and cell genetics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
June 1978,
Biochemical genetics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
July 1980,
Annals of human genetics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
April 1997,
Genomics,
J T Mascarello, and
K Soderberg, and
I E Scheffler
January 1978,
Cytogenetics and cell genetics,
