The treatment and follow-up treatment of head injuries patients requires a drug, which will combat the development of cerebral edema by acting on the blood-brain barrier and restoring the normal function of endothelium and basal membrane. Such a drug should be easy to administer and free from serious side-effects, so that it can be employed for follow-up treatment by the general practitioner without the necessity of hospital facilities (EEG, CT, etc.). In a series of 3557 patients with head injuries Reparil has shown to be a suitable drug in treatment and follow-up treatment of posttraumatic brain edema. In follow-up treatment close medical supervision is essential so that any complications such as intracranial haematomas can be recognized in good time. This applies in particular to patients in high risk groups (advanced age, presence of concurrent diseases, in particular metabolic and circulatory disturbances).