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1. The metabolic fate of a new antitumour agent, 1-hexylcarbamoyl-5-fluoro [6-14C]uracil (14C-HCFU) in rats after oral administration was compared with that of 5-fluoro[6-14C]uracil (14C-FU). 2. Tissue radioactivity reached a max. 1 to 3 h after administration of 14C-HCFU and 0.5 h after 14C-FU. 3. Both drugs were excreted rapidly, mostly in urine. Expired 14CO2 from 14C-HCFU was significantly less than that from 14C-FU. 4. Unchanged FU was not detected in plasma 3 h after administration of 14C-FU, whereas FU was detected in plasma 5 h after 14C-HCFU. The pyrimidine ring of 14C-HCFU might be degradated more slowly than that of 14C-FU. 5. 1-(5-Carboxypentylcarbamoyl)-5-fluorouracil and 1-(3-carboxypropylcarbamoyl)-5-fluorouracil were identified as the major urinary metabolites of 14C-HCFU.
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
November 1980,
Xenobiotica; the fate of foreign compounds in biological systems,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
February 1981,
Journal of the National Cancer Institute,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
June 1981,
Cancer treatment reviews,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
July 1981,
Journal of pharmacobio-dynamics,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
October 1987,
European journal of cancer & clinical oncology,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
January 1988,
Chemotherapy,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
November 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
March 1989,
European journal of cancer & clinical oncology,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
January 1981,
Xenobiotica; the fate of foreign compounds in biological systems,
T Kobari, and
K Tan, and
M Kumakura, and
S Watanabe, and
I Shirakawa, and
H Kobayashi, and
A Ujiie, and
Y Miyama, and
H Namekawa, and
H Yamamoto
January 1980,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
