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The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to the binding of the metal to the peptide. The metal-to-peptide molar ratio of 1:1 provides the best activation. These data indicate the existence of two forms of FTS. The first one lacks Zn and is biologically inactive; the second one contains Zn and is biologically active, for which we propose the name of "thymulin" (FTS-Zn). The presence of Zn in synthetic FTS was confirmed by atomic absorption spectrometry. The interaction between Zn and FTS was further suggested by microanalysis demonstrating the presence of this metal in thymic reticuloepithelial cells.
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
March 1981,
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
February 1983,
International journal of peptide and protein research,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
June 1981,
FEBS letters,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
February 1984,
Biochimica et biophysica acta,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
November 1980,
Clinical and experimental immunology,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
December 1981,
Molecular and cellular biochemistry,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
May 1981,
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
October 1982,
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
December 1978,
The Journal of allergy and clinical immunology,
M Dardenne, and
J M Pléau, and
B Nabarra, and
P Lefrancier, and
M Derrien, and
J Choay, and
J F Bach
January 1985,
Archivos de investigacion medica,
