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Isolation of a nonmitogenic angiogenesis factor from wound fluid. 1982

M J Banda, and D R Knighton, and T K Hunt, and Z Werb

Angiogenesis, or new capillary growth, is essential to normal growth and wound healing. It is also active in several pathologic states, including the growth of malignant tumors. An extracellular, nonneoplastic angiogenesis factor has been isolated from cell-free rabbit wound fluid by pore-limit dialysis and chromatography on a size-exclusion HPLC column. The isolated angiogenesis factor was purified 9,600-fold with a yield of 81% and has a molecular weight between 2,000 and 14,000. Wound fluid angiogenesis factor was completely separated from the mitogenic activity of wound fluid; it did not increase the number of capillary endothelial cells in vitro or stimulate [3H]thymidine uptake by these cells. The isolated angiogenesis factor stimulated endothelial cell migration in vitro, and less than 200 ng of the factor stimulated angiogenesis in vivo in the corneal implant assay.

UI MeSH Term Description Entries
D008934 Mitogens Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed) Mitogen,Phytomitogen,Phytomitogens
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002196 Capillaries The minute vessels that connect arterioles and venules. Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004727 Endothelium A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body. Endotheliums
D006133 Growth Substances Signal molecules that are involved in the control of cell growth and differentiation. Mitogens, Endogenous,Endogenous Mitogens
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D043925 Angiogenesis Inducing Agents Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS. Angiogenesis Inducers,Angiogenesis Effect,Angiogenesis Effects,Angiogenesis Factor,Angiogenesis Stimulating Agents,Angiogenesis Stimulators,Angiogenic Factor,Tumor Angiogenic Factor,Agents, Angiogenesis Inducing,Agents, Angiogenesis Stimulating,Angiogenic Factor, Tumor,Effect, Angiogenesis,Effects, Angiogenesis,Factor, Angiogenesis,Factor, Angiogenic,Factor, Tumor Angiogenic,Inducers, Angiogenesis,Inducing Agents, Angiogenesis,Stimulating Agents, Angiogenesis,Stimulators, Angiogenesis

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