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[Experience with high-dose methotrexate therapy for malignant solid tumors]. 1982
K Kawai, and
T Shibata, and
E Azuma, and
S Arai, and
C Nakano, and
S Hirai, and
K Kazuoka, and
Y Komada, and
T Nakabayashi, and
H Hirota, and
T Matsuda, and
S Shimizu, and
T Nobori, and
M Inoue, and
H Kamiya, and
M Sakurai, and
T Ogiwara, and
Y Kawabe, and
T Nomura, and
M Kato, and
A Uejima
Thirteen patients with malignant solid tumors, mainly osteogenic sarcomas, were treated by high-dose MTX therapy, 50-400 mg/kg, in a total of 72 cycles. It has been proved that this therapy was relatively safe provided careful clinical surveillance were assured. Of 8 patients with osteogenic sarcomas, 6 had no metastatic lesions on the chest X-rays before this therapy: three were alive without any evidence of disease for 18-25 months after high-dose MTX therapy. In some cases of other malignant solid tumors, particularly intracranial tumors, clinical efficacy was observed. Dose-time relationships, etc. should further be studied for more therapeutic efficacies of high-dose MTX therapy.
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