-transparent.png){kind=logo}
Monoclonal antibodies against a variety of antigens can be produced using techniques of somatic cell hybridization between cells of rodent myeloma lines and B cells derived from animals immunized against a given antigen. However, because of the monoclonal antibodies secreted by these hybridomas are of rodent origin, their use in human immunotherapy is limited. Thus the production of B-cell hybrids that secrete human monoclonal antibodies may be of considerable value. We have hybridized a hypoxanthine phosphoribosyl transferase (HPRT)-deficient human B-cell line derived from a patient suffering from multiple myeloma with peripheral lymphocytes obtained from a patient with subacute sclerosing panencephalitis (SSPE). These hybridomas were found to secrete human IgM specific for measles virus nucleocapsids.
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
January 1981,
Current eye research,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
March 1981,
Proceedings of the National Academy of Sciences of the United States of America,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
September 1988,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
January 1985,
Developments in biological standardization,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
December 1987,
Hybridoma,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
October 1985,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
June 1991,
Human immunology,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
June 1988,
Immunology letters,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
May 1987,
Scandinavian journal of immunology,
C M Croce, and
A Linnenbach, and
W Hall, and
Z Steplewski, and
H Koprowski
December 1980,
Indian journal of experimental biology,
