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Pneumocystis carinii pneumonitis (PCP) is a major complication in the immunocompromised host. Recent evidence suggests that most normal individuals have detectable antibody against this organism. The role of the various components of the immune system in protecting the host from acute PCP is unclear. We have examined the in vitro proliferative response of lymphocytes from normal adults to P. carinii antigen. Fourteen of 16 subjects had a positive response with stimulation indices greater than 3. This response was due primarily to thymus-derived (T cell) lymphocytes and was dependent upon the presence of adherent cells. The response was most likely not due to a mitogenic component in our antigen preparation, since lymphocytes from only 2 of 16 cord blood specimens had stimulation indices greater than 3.
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
December 1992,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
January 1997,
The Journal of eukaryotic microbiology,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
March 1993,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
March 1989,
Journal of clinical microbiology,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
January 1993,
Scandinavian journal of infectious diseases,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
October 1991,
International journal of experimental pathology,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
December 1992,
Japanese journal of clinical oncology,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
March 1997,
The Journal of infectious diseases,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
September 1998,
FEMS immunology and medical microbiology,
H G Herrod, and
W R Valenski, and
D R Woods, and
L L Pifer
June 1991,
Antimicrobial agents and chemotherapy,
